Guselkumab in the Treatment of Pityriasis Rubra Pilaris (PRP)

    Not Recruiting
  • End date
    Dec 7, 2022
  • participants needed
  • sponsor
    Oregon Health and Science University
Updated on 18 April 2022


15 patients with PRP will be treated with guselkumab for 20 weeks to determine safety and efficacy. Participants are required to travel to Portland, OR only for the first visit, week-4 visit, and week-24 visit. 3 visits in between these times and one follow up visit may be performed by secure videoconferencing.


Pityriasis rubra pilaris (PRP) is a rare and poorly understood severe inflammatory skin disease characterized by widespread (often full-body) redness and flaking of the skin, painful thickening and cracking of the palms and soles, hair loss, crumbling nails, and severe skin itching and burning.

There is no FDA-approved therapy for this rare disease and the commonly used medications do not work for many patients. There is some evidence that IL-23 may be too high in the skin of PRP patients. Ixekizumab is an injectable medication that blocks IL-23 by binding the p19 subunit and is FDA-approved for psoriasis.

Condition Pityriasis Rubra Pilaris
Treatment Guselkumab
Clinical Study IdentifierNCT03975153
SponsorOregon Health and Science University
Last Modified on18 April 2022

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