Evaluate the Safety, Tolerability, and Antiviral Activity of GLS4 With Ritonavir in Patients With Chronic HBV Infection

  • days left to enroll
  • participants needed
  • sponsor
    Sunshine Lake Pharma Co., Ltd.
Updated on 16 February 2022


The experiment is divided into two parts: Part 1 and Part 2.Part 1 was the initial treatment patient and Part 2 was the treated patient.


About 125 subjects were planned to be included and assigned to the experimental group and the control group according to 4:1.At the same time, a liver biopsy group was set up in each part of the population to receive liver biopsy during the screening period and 48 weeks after completion of drug administration, which was used to detect HBV DNA, cccDNA, HBsAg, and evaluate the degree of liver inflammation and fibrosis.

Condition Chronic HBV Infection
Treatment RTV, GLS4, ETV
Clinical Study IdentifierNCT04147208
SponsorSunshine Lake Pharma Co., Ltd.
Last Modified on16 February 2022


Yes No Not Sure

Inclusion Criteria

Chronic HBV infection population
HBeAg positive
HBsAg250 IU/mL
No cirrhosis

Exclusion Criteria

Platelet count less than 90E+09/L
albumin<35 g/L
AFP>50 ng/mL
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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