Last updated on November 2019

Liver Health and Metabolic Function in People With Obesity


Brief description of study

This project aims to determine the effect of significant weight loss on rates on hepatic fibrogenesis in people with obesity.

Detailed Study Description

Non-alcoholic fatty liver disease (NAFLD) affects approximately 70% of those with obesity and if left untreated can progress to cirrhosis and liver failure. NAFLD stages progress from the stage of simple steatosis to steatohepatitis, and fibrosis The stage of NAFLD is currently best determined using histology from a liver biopsy, however this provides a static depiction of the state of the liver. Therefore This project aims to determine fibrogenesis in the liver of obese humans in vivo, before and after weight loss.

Clinical Study Identifier: NCT03701828

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