Liver Health and Metabolic Function in People With Obesity

  • End date
    Nov 1, 2024
  • participants needed
  • sponsor
    Washington University School of Medicine
Updated on 3 May 2022
body mass index
bariatric surgery
Accepts healthy volunteers


This project aims to determine the effect of significant weight loss on rates on hepatic fibrogenesis in people with obesity.


Non-alcoholic fatty liver disease (NAFLD) affects approximately 70% of those with obesity and if left untreated can progress to cirrhosis and liver failure. NAFLD stages progress from the stage of simple steatosis to steatohepatitis, and fibrosis The stage of NAFLD is currently best determined using histology from a liver biopsy, however this provides a static depiction of the state of the liver. Therefore This project aims to determine fibrogenesis in the liver of obese humans in vivo, before and after weight loss.

Condition Non-Alcoholic Fatty Liver Disease
Treatment Weight loss surgery, Weight loss surgery
Clinical Study IdentifierNCT03701828
SponsorWashington University School of Medicine
Last Modified on3 May 2022


Yes No Not Sure

Inclusion Criteria

Body mass index ≥35 kg/m2
Scheduled for Bariatric surgery

Exclusion Criteria

Significant organ disfunction/disease
Tobacco use
Previous bariatric surgery
Excessive alcohol use
Liver disease other than NAFLD
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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