Stroke Rehabilitation Using BCI Technology

  • STATUS
    Recruiting
  • End date
    Jun 30, 2023
  • participants needed
    144
  • sponsor
    University of Wisconsin, Madison
Updated on 20 August 2022
MRI
electrical stimulation
ischemic stroke
hemiparesis
stroke rehabilitation
Accepts healthy volunteers

Summary

The purpose of this research is to determine if functional muscle stimulation, directed by electroencephalogram (EEG) output, can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic resonance imaging (fMRI). Participants will include stroke patients with upper-limb hemiparesis and can expect to be on study for approximately 4 months.

Description

Ongoing research (NCT02098265) suggests that noninvasive EEG driven Brain Computer Interface (BCI) systems hold the potential for facilitating recovery in the chronic phase after stroke by synchronizing central or brain activity with peripheral movements and thereby harnessing brain plasticity.

The specific aims of this study are:

Aim 1: To investigate the efficacy of active FES vs. passive FES, as measured by changes in behavioral measures. The investigators hypothesize that improvements in motor function will be significantly greater using the active FES therapy than the passive FES therapy.

Aim 2: To investigate the relationship between brain functional activation patterns and behavior changes induced by active vs. passive FES intervention. The investigators hypothesize that changes induced by active FES (as measured by brain fMRI and EEG measures) will show greater adaptive brain reorganization changes (i.e. brain changes that correlate with improved outcomes) than that induced by the passive FES.

Aim 3: To investigate the relationship between brain white matter integrity and behavior changes induced by active vs. passive FES intervention. The investigators hypothesize that changes induced by active FES (as measured by brain DTI measures) will show greater adaptive brain reorganization changes (i.e. brain changes that correlate with improved outcomes) than that induced by the passive FES.

Details
Condition Stroke
Treatment magnetic resonance imaging, EEG, Behavioral Assessments, Functional Electric Stimulation (FES)
Clinical Study IdentifierNCT04141774
SponsorUniversity of Wisconsin, Madison
Last Modified on20 August 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

New-onset ischemic stroke 12 months prior - chronic time frame
Right hand dominant - affected arm
Mild to moderate unilateral upper extremity impairment or severe unilateral upper extremity impairment
No upper extremity injury or conditions that limited use prior to the stroke
Must be able to provide informed consent on their own behalf

Exclusion Criteria

Inability to competently participate in study procedures
Concurrent upper extremity therapy, other neurological or psychiatric disorders
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