Randomized Control Trial for Awake vs. Asleep Craniotomy for Non-eloquent Gliomas

  • End date
    Dec 30, 2023
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 23 October 2022


This study protocol examines a comparison between local and general anesthesia (Awake vs. Asleep Craniotomy) in the removal of brain tumors that are in areas of the brain that do not directly control bodily functions (non-eloquent gliomas).


This is a single-center, prospective randomized open or non-blinded end-point (PROBE) clinical trial. Patients will be selected by the neurosurgeon according to the inclusion and exclusion criteria. Patients who consent to randomization will have confirmed non-eloquent status confirmed by independent surgeon and will be randomized into 1 of 2 treatment groups utilizing a dynamic minimization approach. The experimental group with randomization of patients who will undergo awake craniotomy for both high and low grade gliomas in non-eloquent areas or a control group of patients who will have asleep craniotomy for both high and low grade gliomas in non-eloquent regions.

Condition Intracranial Glioma
Treatment Awake Anesthesia Protocol, Non-awake Anesthesia Protocol
Clinical Study IdentifierNCT03621748
SponsorMayo Clinic
Last Modified on23 October 2022


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