Catheter Ablation of Atrial Fibrillation in Patients With Pulmonary Hypertension Hypertension: a Randomised Study

  • STATUS
    Recruiting
  • End date
    Dec 31, 2021
  • participants needed
    100
  • sponsor
    General University Hospital, Prague
Updated on 23 January 2021
arrhythmia
catheter ablation
atrial flutter

Summary

Atrial fibrillation (AF) and atrial tachycardia (AT), including type I atrial flutter, are frequently observed in patients with pulmonary hypertension (PH). Catheter ablation of AF / AT has been established as an effective treatment option in selected patients. However, little is known about the efficacy and safety of this approach in patients with PH. It has also been shown that considerable proportion of patients with PH after acutely successful catheter ablation suffer from the recurrence of clinical or newly manifested arrhythmia. We propose a prospective study to compare two ablation strategies in a randomized fashion: radiofrequency catheter ablation targeting only the clinical arrhythmia versus more extensive substrate-based catheter ablation. This project will investigate the clinical outcome of patients with pulmonary hypertension and symptomatic atrial fibrillation / tachycardia who will be randomly allocated to selective versus complex radiofrequency catheter ablation of arrhythmogenic substrate.

Details
Condition Arrhythmia, Atrial Fibrillation, Pulmonary Hypertension, Cancer Prevention, Surviving Abuse, Joint Injuries, Abdominal Surgery, Mental Disability, Pelvic Adhesions, Low Testosterone, Dental Filling, Habit Reversal, Complicated Grief, Chronic Pelvic Pain, Gambling Problems, Myopic Macular Degeneration, Nerve Injury, Severe Premenstrual Symptom, Stasis Dermatitis, Pulmonary Arterial Hypertension, Open Heart Surgery, Recurrent Pregnancy Loss, Effects of Chemotherapy, Renal Anemia, Functional Dyspepsia, Catheter Complications, Serial Evaluation of Ductal Epithelium, Chronic Renal Anemia, Cancer Treatment, Atrial Fibrillation (Pediatric), Anemic Cancer, Spinocerebellar Disorders, Pseudobulbar Affect, Spine Athroplasty, Indikation: Diabetes - Typ II, Partial Medial Meniscectomy, Primary Insulin Hypersecretion, Testotoxikose, Infantile Fibrosarcoma, Late Infantile Neuronal Ceroid Lipfuscinsosis, Dysrhythmia, Memory Problems
Treatment catheter ablation
Clinical Study IdentifierNCT04053361
SponsorGeneral University Hospital, Prague
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Pre-capillary PH (PAMP 25 mmHg; PAWP 15 mmHg) or combined post- a pre-capillary PH (PAMP 25 mmHg; PAWP >15 mmHg; DPG 7 mmHg and/or PVR >3 W.u.) of any etiology

Exclusion Criteria

Complex congenital heart defects (corrected or uncorrected)
Isolated post-capillary PH (PAMP 25 mmHg; PAWP >15 mmHg; DPG <7 mmHg and/or PVR 3W.u.)
Previous catheter ablation for AF / AT / AFL
Previous or scheduled cardiac surgery-
NYHA Class IV, cardiogenic shock
Life expectancy <1 year
Non-compliance
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