Modulating the GIP System in Patients With Acromegaly Due to a Pituitary Tumor (GA-9)
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- STATUS
- Recruiting
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- End date
- Dec 16, 2025
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- participants needed
- 30
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- sponsor
- University of Copenhagen
Summary
Modulation of the GIP System in Patients With Acromegaly Due to a Pituitary adenoma
Description
Aim: To determine the importance of the GIP system in patients with acromegaly who has paradoxical growth hormone secretion during an oral glucose tolerance test (OGTT) using a GIP antagonist (GIP-A).
Thirty participants (age 18-75 years) with normal kidney and liver parameters and hemoglobin levels will be included in a placebo-controlled cross-over study. The study consists of two study days with concomitant infusions of A) GIP-A or B) saline (placebo).
A paradoxical growth hormone secretion to an OGTT is here defined as an increase in plasma growth hormone levels of 30% from baseline based on a mean value of the definitions in the literature.
Regazzo et al. (2017) European Journal of Endocrinology 176, 543-553 Mukai et al. (2018) The Journal of Clinical Endocrinology and Metabolism 104(5), 1637-1644 Hage et al. (2019) The Journal of Clinical Endocrinology and Metabolism 104(5), 1777-1787 Scaroni et al. (2019) J Clin Endocrinol Metab 104(3), 856-862
Details
| Condition | Acromegaly Due to Pituitary Adenoma |
|---|---|
| Treatment | Placebo, GIP-A |
| Clinical Study Identifier | NCT03807076 |
| Sponsor | University of Copenhagen |
| Last Modified on | 15 February 2022 |
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