Acute Effects of the Prostaglandin (Alprostadil) on Cerebral and Pulmonary Flow (Alprostadil)

  • STATUS
    Recruiting
  • End date
    Dec 31, 2024
  • participants needed
    28
  • sponsor
    The Hospital for Sick Children
Updated on 15 February 2022
single ventricle

Summary

The second stage operation towards single ventricle palliation is 'bidirectional cavopulmonary connection' (BCPC). The superior vena cava is connected to the pulmonary artery, diverting 'blue' blood from the upper body (including the brain) to the lungs. A successful BCPC requires sufficient and easy blood flow through the lungs. Alprostadil is the synthetic form of prostaglandin (hormone that causes dilation of blood vessels) and has been shown to increase blood flow in the brain hence increasing blood flow to the lungs after BCPC, potentially useful in managing children post BCPC with low flow to the lungs and thus poor oxygenation. This study propose to investigate acute effects of Alprostadil on different blood vessels after BCPC.

Details
Condition Congenital Heart Disease
Treatment Alprostadil 5 MCG Injection
Clinical Study IdentifierNCT04054115
SponsorThe Hospital for Sick Children
Last Modified on15 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

BCPC patients at time of routine pre-Fontan assessment
Cardiac catheterization and cardiac magnetic resonance imaging (CMR)
Patients between the ages of 1 and 6 years old

Exclusion Criteria

Patients who are hypersensitive to this product or to any ingredient in its formulation
Patients with seizure disorders or coagulopathies
Patients with abnormal kidney function
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