Mechanism of Action of Electroconvulsive Therapy (MoA-ECT)

  • STATUS
    Recruiting
  • End date
    Dec 1, 2023
  • participants needed
    136
  • sponsor
    Massachusetts General Hospital
Updated on 27 October 2022
depression
psychosis
depressive disorder
depressed mood
psychiatric treatment
psychotic
electroconvulsive therapy
Accepts healthy volunteers

Summary

This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.

Description

This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a full course of ECT and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of ECT at the circuit level (2) to determine the mechanism of action of iatrogenic amnesia caused by ECT at the circuit level (3) to study the use of fcMRI as a state biomarker for depression (4) to study the use of fcMRI as a predictor of response for depression.

Details
Condition Unipolar Depression, Bipolar Depression
Treatment Electroconvulsive therapy
Clinical Study IdentifierNCT04059952
SponsorMassachusetts General Hospital
Last Modified on27 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Males and Females Between Ages of 18 and 65
Diagnosis of Major Depressive Disorder without Psychotic Features or Bipolar I/II
Requiring ECT Treatment as Part of Psychiatric Care

Exclusion Criteria

Comorbid diagnoses of Major Depressive Disorder with Psychotic Features, Schizoaffective Disorder, Schizophrenia or Dementia
History of Psychosis
Substance Use Disorder (Abuse or Dependence) with Active Use Within Last 6 Months
Severe or Unstable Medical Illness
Medical Contraindication to Anesthesia or ECT (e.g., Recent Myocardial Infarction)
Clear my responses

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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