Mechanism of Action of Electroconvulsive Therapy (MoA-ECT)

  • End date
    Dec 1, 2023
  • participants needed
  • sponsor
    Massachusetts General Hospital
Updated on 27 October 2022
depressive disorder
depressed mood
psychiatric treatment
electroconvulsive therapy
Accepts healthy volunteers


This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.


This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a full course of ECT and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of ECT at the circuit level (2) to determine the mechanism of action of iatrogenic amnesia caused by ECT at the circuit level (3) to study the use of fcMRI as a state biomarker for depression (4) to study the use of fcMRI as a predictor of response for depression.

Condition Unipolar Depression, Bipolar Depression
Treatment Electroconvulsive therapy
Clinical Study IdentifierNCT04059952
SponsorMassachusetts General Hospital
Last Modified on27 October 2022


Yes No Not Sure

Inclusion Criteria

Males and Females Between Ages of 18 and 65
Diagnosis of Major Depressive Disorder without Psychotic Features or Bipolar I/II
Requiring ECT Treatment as Part of Psychiatric Care

Exclusion Criteria

Comorbid diagnoses of Major Depressive Disorder with Psychotic Features, Schizoaffective Disorder, Schizophrenia or Dementia
History of Psychosis
Substance Use Disorder (Abuse or Dependence) with Active Use Within Last 6 Months
Severe or Unstable Medical Illness
Medical Contraindication to Anesthesia or ECT (e.g., Recent Myocardial Infarction)
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note