Application of Ultrasound Integrated Precision Diagnosis Technology in Prevention of Kidney Disease and Its Progress

  • STATUS
    Recruiting
  • days left to enroll
    10
  • participants needed
    300
  • sponsor
    RenJi Hospital
Updated on 23 January 2021
cytokines
kidney transplant
glomerular filtration rate
renal injury
proteinuria
renal fibrosis

Summary

In this study, a prospective, randomized and controlled clinical study would be carried out to establish Ultrasound Integrated Precision Diagnosis Technology with elastography as the core technology to evaluate renal injury and repair comprehensively and accurately, and to improve the clinical diagnosis chance of renal injury (or renal fibrosis).

Combined with the dynamic changes of biomarkers (inflammatory factors, cytokines secreted by immune cells, etc.) after kidney injury, the research on the prognosis of kidney disease with ultrasound elastography technology as the core would be explored, which aims to provide a scientific basis for the application of Ultrasound Integrated Precision Diagnosis Technology.

Details
Condition Nephropathy, Diagnosis, Differential diagnostic aspects, Diagnostic Imaging, Kidney Disease (Pediatric), Kidney Disease, renal disease, kidney diseases, kidney disorders, nephrologic disease, kidney disorder, disease, kidney, medical imaging, imaging procedure
Treatment Ultrasound Integrated Precision Diagnosis Technology(ultrasound elastography)
Clinical Study IdentifierNCT04044404
SponsorRenJi Hospital
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

for A on C group 1.18-70 years old; gender is not limited; 2. Patients who can cooperate with breath-holding, breath-holding and breath-exhaling movements, and communicate without obstacles
The informed consent has been signed; 4.Abnormal renal pathology or
glomerular filtration rate(GFR) (15 <GFR<90 ml/min.1.73 m2) or proteinuria > 1
g/24 h due to any cause
\. for kidney transplantation
18-70 years old; gender is not limited
It can cooperate with breath-holding, breath-holding and breath-exhaling movements, and communicate without obstacles
The informed consent has been signed
Kidney transplant recipients in our hospital from May 2019 to November 2019

Exclusion Criteria

for A on C group
Can't cooperate, can't lie down for at least 10 minutes, unconsciousness, severe hypoxia, restlessness need to rescue patients
Patients with pregnancy or cancer
There are other serious diseases that the researchers do not think it is suitable to participate in this experiment
Absolute contraindications of renal puncture, Obvious bleeding tendency; Severe hypertension (systolic pressure greater than 180 mm Hg or diastolic pressure greater than 115 mm Hg); Psychiatric patients or non-cooperating operators and isolated kidney (small kidney) Or relative contraindications of renal puncture: Active pyelonephritis, renal tuberculosis, hydronephrosis or pyonephrosis, renal abscess or perirenal abscess. Renal tumors or renal aneurysms. Polycystic kidney or renal cyst. Kidney position is too high (deep inhalation of the lower pole of the kidney is not below the twelve ribs) or migratory kidney. Obesity, severe ascites
bfor kidney transplantation
Can't cooperate, can't lie down for at least 10 minutes, unconsciousness, severe hypoxia, restlessness need to rescue patients
Patients with pregnancy or cancer
There are other serious diseases that the researchers do not think it is suitable to participate in this experiment
Absolute contraindications of renal puncture, Obvious bleeding tendency; Severe hypertension (systolic pressure greater than 180 mm Hg or diastolic pressure greater than 115 mm Hg); Psychiatric patients or non-cooperating operators and isolated kidney (small kidney) Or relative contraindications of renal puncture: Active pyelonephritis, renal tuberculosis, hydronephrosis or pyonephrosis, renal abscess or perirenal abscess. Renal tumors or renal aneurysms. Polycystic kidney or renal cyst. Kidney position is too high (deep inhalation of the lower pole of the kidney is not below the twelve ribs) or migratory kidney. Obesity, severe ascites
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