Caffeine Consumption in Glaucoma Patients and Healthy Subjects

  • STATUS
    Recruiting
  • days left to enroll
    55
  • participants needed
    80
  • sponsor
    Wills Eye
Updated on 15 February 2022
eye disease
pigmentary glaucoma
primary open angle glaucoma
Accepts healthy volunteers

Summary

Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.

Description

Ingestion of caffeine in glaucoma patients and healthy subjects may decrease peripapillary and macular blood flow in the back of the eye.

The primary objective of this study is to assess the acute changes in peripapillary and macular blood flow before and after an intake of oral caffeine (200 milligram tablet) in glaucoma patients and healthy subjects by using optical coherence tomography angiography (OCTA) scans. This novel imaging tool creates three-dimensional angiograms to assesses signal changes caused by flowing blood cells in a non-invasive angiogram scan. Blood flow is shown as vessel density measured in percentage.

Details
Condition Glaucoma, Primary Open Angle
Treatment Caffeine tablet
Clinical Study IdentifierNCT03675412
SponsorWills Eye
Last Modified on15 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

age 18 to 90 years
diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced)
healthy subjects with no eye disease

Exclusion Criteria

Diseases, ophthalmic or systemic, that are likely to affect OCTA results
greater than moderate cataract
nystagmus
inability to look at target
macular degeneration other than mild drusen or pigmentary changes
diabetic retinopathy
neovascular glaucoma or non-glaucoma optic neuropathies
current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy
keratoconus, corneal ectasia, central corneal scarring
rheumatologic diseases or Raynaud's phenomena
pregnant and lactating women
mental illness or alcohol addiction
pre-existing bladder symptoms, cardiac disease or sleep disorder
refractive spherical diopter greater than 5 or cylinder greater than 3
possible tolerance to caffeine (drinking more than 1 cup coffee per day)
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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