Oxytocin, Stress, Craving, Opioid Use Disorder (OSCO)

  • STATUS
    Recruiting
  • participants needed
    40
  • sponsor
    Brown University
Updated on 25 June 2022
opiates
substance use
buprenorphine
narcotic use
oxytocin

Summary

Although stress has long been linked to substance use, craving and relapse, there are no available medications that target stress-induced substance use disorder (SUD). In particular, with the rise in opioid use, there is still a crucial need for developing effective pharmacological treatments that target and integrate the complexity of this disease. The long term goal of this project is to identify the key neuroendocrine pathways that are responsible for stress-induced craving in individuals with opioid use disorder (OUD) in order to better understand how they can be effectively treated.

Description

The goal of this research is to evaluate whether oxytocin, a hormone with anti-stress properties, dampens the effects of stress and opioid-associated cues on opioid craving and thus may be an effective adjunctive treatment for OUD.

The central hypothesis of this research is that oxytocin will reduce stress-induced opioid craving in patients with OUD treated with buprenorphine/naloxone as opioid replacement therapy (ORT). This hypothesis is based on the model of addiction (Koob, Neuron 2008) in which chronic substance use and stress lead to neurobehavioral counter-adaptations that dysregulate biobehavioral response.

In this double-blind, placebo controlled, randomized trial, individuals with OUD (N=68) who are currently receiving treatment with buprenorphine/naloxone will be randomized to intranasal oxytocin (40 international units, IU) or oxytocin-matched placebo, administered twice/day for 7 days. On days 5 and 7, participants will complete two counter-balanced sessions in which they receive yohimbine (32.4 mg) or yohimbine-matched placebo, and responses to opioid cues are assessed.

Details
Condition Opioid Use Disorder
Treatment intranasal oxytocin, 40 IU, twice a day for 7 days
Clinical Study IdentifierNCT04051619
SponsorBrown University
Last Modified on25 June 2022

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