Clinical Study of Antiviral and Aspirin Treatment in Liver Cancer After Radical Surgery

  • End date
    Dec 23, 2023
  • participants needed
  • sponsor
    Fudan University
Updated on 14 February 2022
liver cancer
antiviral drugs


Evaluation the Treatment Outcome of Antiviral and Aspirin Treatment in Liver Cancer After Radical Surgery.


The investigators conduct this clinical trial to evaluate the treatment outcome of Antiviral and Aspirin Treatment in Liver Cancer After Radical Surgery.The primary outcome is overall survival and objective response rate.

Condition Hepatocellular Carcinoma, Recurrence
Treatment Aspirin, lamivudine
Clinical Study IdentifierNCT01936233
SponsorFudan University
Last Modified on14 February 2022


Yes No Not Sure

Inclusion Criteria

Hepatocellular carcinoma confirmed with pathology or identified with radiological images with typical features
Age 18 years and 75 years
At least one tumor nodule with one uni-dimension of 2 cm
Child-Pugh Class A or B
Total bilirubin 1.5 x upper limit of normal
ALT and AST 2.0 x the upper limit of normal
PT-INR<2.3,PTT < 1.5 x upper limit of normal
Serum creatinine 1.5x upper limit of normal
Peripheral white blood cell count of or more than 310(9)/L
Peripheral platelet of or more than 5010(9)/L
Expected survival time not less than 3 months
ECOG score 0-2

Exclusion Criteria

Tumor thrombi in main branch of portal vein
Tumor involvement more than 70% of whole liver
With extrahepatic metastasis
Prior systemic chemotherapy or chemoembolization
Congestive heart failure > NYHA class 2
History of HIV infection
Active clinically serious infections (> 2 NCI-CTC Version 3.0)
Recurrence of HCC after liver transplantation
Pregnant or breast-feeding
Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in this study
Known or suspected allergy to any agent given in association with this trial
Patients unable to swallow oral medication
Inclined to thrombosis
Inclined to hemorrhage or active hemorrhage with 1 month
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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