SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    University of Kansas Medical Center
Updated on 6 February 2023
behavior therapy
dementia
cognitive therapy
cognitive behavioral therapy for insomnia
initial insomnia
Accepts healthy volunteers

Summary

The objective of this study is to compare the efficacy of a sleep intervention on improving cognitive function in older adults with symptoms of insomnia, determine the association between change in sleep measures and change in cognitive function, and examine the efficacy of the sleep intervention on reducing the rate of A deposition. Participants, ages 60-85, will be randomly assigned to a six-week sleep intervention program. A sub-group of fifty participants will undergo Florbetapir-Positron-emission tomography (PET) imaging during the one-year reassessment to examine the efficacy of the sleep intervention on reducing the rate of A accumulation from baseline to one-year post-intervention.

Description

Lifestyle interventions to increase exercise and improve diet have been the focus of recent clinical trials to potentially prevent Alzheimer's disease (AD). However, despite the strong links between sleep disruptions, cognitive decline, and AD, sleep enhancement has yet to be targeted as a lifestyle intervention to prevent AD. Approximately fifteen percent of AD may be prevented by an efficacious intervention aimed to reduce sleep disturbances and sleep disorders. Chronic insomnia is the most frequent sleep disorder occurring in at least forty percent of older adults. Individuals with insomnia are more likely to be diagnosed with AD and demonstrate a decline in cognitive function at long-term follow-up. AD is characterized by the accumulation of A plaques and tau tangles in the brain, and growing evidence shows impaired sleep contributes to the accumulation of A. An intervention aimed at improving insomnia may represent a critical opportunity for primary prevention to slow cognitive decline and potentially delay the onset of AD. Therefore, the long-term goal of this research agenda is to understand how addressing sleep disturbances, via sleep intervention, may delay the onset of AD.

Details
Condition Insomnia
Treatment Active control, Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep and Lifestyle Education
Clinical Study IdentifierNCT03954210
SponsorUniversity of Kansas Medical Center
Last Modified on6 February 2023

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