Long-term Follow-up of Interleukin-1B and H+,K+-ATPase mRNA Expression After Helicobacter Pylori Eradication

  • End date
    Dec 30, 2022
  • participants needed
  • sponsor
    Seoul National University Bundang Hospital
Updated on 14 February 2022
gastric cancer
peptic ulcer
early gastric cancer


We will evaluate the long-term changes of gastric H+, K+-adenosine triphosphatase (H+, K+-ATPase) and Interleukin-1B mRNA expression according to Helicobacter pylori (H.pylori) infection and intestinal metaplasia and investigate the long-term effect of H. pylori eradication


H. pylori suppresses gastric acid secretion by repressing gastric acid pump, H+, K+-ATPase, and stimulating Interleukin-1B. In this study, we will evaluate the expression of H+, K+-ATPase and Interleukin-1B mRNA according to H. pylori infection and intestinal metaplasia in controls and patients with gastric cancer. In addition, we observe the changes of H+, K+-ATPase and Interleukin-1B mRNA expression over 5 years after H. pylori eradication.

Condition Helicobacter Pylori Infection
Clinical Study IdentifierNCT04037904
SponsorSeoul National University Bundang Hospital
Last Modified on14 February 2022


Yes No Not Sure

Inclusion Criteria

Controls who did not have any evidence of gastric cancer, gastric dysplasia, esophageal tumor, peptic ulcer and lymphoma on esophagogastroduodenoscopy
Patients with gastric dysplasia or gastric cancer who diagnosed with gastric dysplasia or early gastric cancer in the final pathological report

Exclusion Criteria

Subjects with previous eradication treatment for H. pylori
Subjects with previous gastrectomy
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