Abscopal Effect of Radiotherapy and Nivolumab in Relapsed Hodgkin Lymphoma After Anti-PD1 Therapy

  • STATUS
    Recruiting
  • End date
    Dec 18, 2023
  • participants needed
    29
  • sponsor
    University of Cologne
Updated on 18 April 2021
lymphoma
nivolumab
avid

Summary

The aim of the trial is to improve efficacy of nivolumab in patients with relapsed or refractory HL who recently progressed on anti-PD1 therapy. Nivolumab is highly effective and well tolerated in rrHL, nevertheless CR-rates are low and a considerable proportion of patients suffers from progressive disease. Localized RT induces an immunogenic effect which might work synergistically and facilitate augmented systemic (i.e. abscopal) responses in combination with nivolumab.

Details
Condition Classical Hodgkin Lymphoma
Treatment Nivolumab plus radiotherapy
Clinical Study IdentifierNCT03480334
SponsorUniversity of Cologne
Last Modified on18 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Progression of refractory or relapsed cHL during treatment with an anti-PD1 agent
At least two distinct FDG-avid HL-lesions with at least 5 cm distance between them, and one of them considered eligible for irradiation with 20Gy based on localization and prior RT exposure
Age at registration 18 years

Exclusion Criteria

Nodular-lymphocyte predominant HL (NLPHL) or composite/greyzone lymphoma
Lymphoma involving the central nervous system
Nave to treatment with anti-PD1 targeting antibodies
Clear my responses

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