Contraceptive Pills and Retinal Vascularization (PILURET)

  • End date
    Mar 13, 2023
  • participants needed
  • sponsor
    Fondation Ophtalmologique Adolphe de Rothschild
Updated on 4 October 2022


The main hypothesis is the taking of combined 1st and 2nd generation or 3rd and 4th generation oral contraceptives is associated with a change in retinal micro-vascularization compared to the absence of combined oral contraceptive intake.

Women of childbearing age will be recruited during their ophthalmologic consultation at the Rothschild Foundation, an OCT-A will be realized and data relating to their medical and ophthalmologic history and their oestro-progestative contraceptive intake will be collected.

The objective is to find an association between retinal vascular density and combined oral contraceptives intake.

Condition Combined Oral Contraceptives Intake
Treatment OCT-A (Optical Coherence Tomography)
Clinical Study IdentifierNCT03964636
SponsorFondation Ophtalmologique Adolphe de Rothschild
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

for the control group : No Estro-progestin contraceptive treatment (oral, transdermal) for at least 6 months
for the cases under combined 1st and 2nd generation pills : Estro-progestin contraceptive treatment for at least 6 months
for the cases under combined 3rd and 2th generation pills: Estro-progestin contraceptive treatment for at least 6 months

Exclusion Criteria

Menopausal woman
Ametropia greater than + 3 hyperopia diopters or-3 myopia diopters
Astigmatism greater than 2 dioptres
Smoking patient (cigarette or e-cigarette)
Caffeine intake within 2 hours prior to the OCT-A exam
Any known retinal pathology
Antecedent of deep vein thrombosis or deep arterial thrombosis
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