Evaluation of Response to Abiraterone/Prednisone by Race/Ethnicity and Other Factors in Metastatic Hormone Naive Prostate Cancer (APRE)

  • STATUS
    Recruiting
  • End date
    Apr 25, 2034
  • participants needed
    130
  • sponsor
    Martha Mims
Updated on 25 July 2022
renal function
gonadotropin
prednisone
androgens
testosterone
metastasis
neutrophil count
docetaxel
antiandrogen therapy
bone scan
bicalutamide
flutamide
antiandrogens
abiraterone
metastatic prostate cancer
luteinizing hormone-releasing hormone agonist
goserelin
orchiectomy
bone metastases
finasteride
serum testosterone
luteinizing hormone
dutasteride
bisphosphonate
lhrh analogue
gonadorelin
immunological adjuvant
prostate cancer metastatic
diphosphonates

Summary

The investigators are conducting this study with men that have prostate cancer and are getting standard of care treatment with the drugs abiraterone acetate and prednisone. The study will follow men with prostate cancer from initiation of participation in the study and for up to 10 years. The reason for the study is that researchers think that there may be a connection between the race and ethnicity of men with prostate cancer and how well the standard treatments work for the participants.

Description

This is a single arm study in metastatic hormone naïve prostate cancer. Standard of care in these men is either to offer Androgen deprivation therapy (ADT) + abiraterone acetate/low-dose prednisone or, in men with higher tumor burden, to offer ADT + Docetaxel/prednisone. The investigator's experience is that even men with increased tumor burden often opt for abiraterone because of the improved side effect protocol as compared to chemotherapy.

Approximately 130 PSA response evaluable subjects will be enrolled, of which the investigators expect 50% to be African American based on clinic population and previous experience with clinical trial enrollment.

The study will enroll men with newly diagnosed hormone naïve prostate cancer within 42 days of receiving the first dose of ADT (LHRH agonist) or undergoing orchiectomy. Patients will continue ADT throughout the study. Abiraterone acetate and low dose prednisone will continue until progression as defined by standard PCWG2 criteria.

Details
Condition Prostate Cancer Metastatic, Prostate Cancer
Treatment prednisone, abiraterone acetate
Clinical Study IdentifierNCT03833921
SponsorMartha Mims
Last Modified on25 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

All patients must have a histologically or cytologically proven diagnosis of adenocarcinoma of the prostate. All patients must have metastatic disease as evidenced by soft tissue and/or bony metastases prior to initiation of androgen deprivation therapy (ADT). NOTE: ADT does not include treatment with anti-androgens such as bicalutamide or flutamide or five alpha reductase inhibitors such as finasteride or dutasteride
Patients must have radiographic assessments of all disease including bone scan (or PET scan) within 42 days prior to registration. All disease will be assessed and documented on the appropriate CRF
Patients must have had no more than 42 days of prior castration (medical or surgical) for metastatic prostate cancer prior to starting abiraterone. The start date of medical castration is considered the day the patient first received an injection of a LHRH agonist/antagonist (or orchiectomy), not an oral antiandrogen. • If the method of castration was luteinizing hormone releasing hormone (LHRH) agonists (i.e., leuprolide or goserelin), the patient must be willing to continue the use of LHRH agonist and add Abiraterone + Prednisone treatment. • If the patient was on an antiandrogen (e.g. bicalutamide, flutamide), the patient must be willing to switch over to Abiraterone + Prednisone treatment. There is no limit on how many days a patient may have been on an antiandrogen (e.g. bicalutamide, flutamide) or a five alpha reductase inhibitor (e.g. finasteride or dutasteride) prior to going on study and no washout is required
Patients may have received prior ADT - neoadjuvant and/or adjuvant setting only - but it must not have lasted for more than 36 months. Single or combination therapy allowed. At least 6 months must have elapsed since completion of ADT in the neoadjuvant and/or adjuvant setting, and serum testosterone must be > 50 ng/dL (non-castrate levels) within 28 days prior to registration. NOTE: Serum testosterone assessment is required for eligibility for only those patients with prior treatment with neoadjuvant or adjuvant ADT
Patients who are deemed to have high-risk or extensive metastatic, hormone sensitive prostate cancer (mHSPC) per "clinical judgment" of the treating physician are eligible for enrollment if the participants are unsuitable candidates for docetaxel or if the participants have declined docetaxel therapy
Patients may have received prior surgery. For all major surgeries, at least 14 days must have elapsed since completion and patient must have recovered from all major side effects of surgery per investigator's assessment
Patients may have received or plan to receive concurrent bone targeting agents that do not have an effect on PSA (e.g. denosumab or bisphosphonate)
Patients must have no plans to receive any other experimental therapy while on the protocol treatment. Previous experimental therapy must have been completed at least 28 days prior to registration
Patients must have a complete physical examination and medical history within 28 days prior to registration
Patients must have a PSA ≥ 10 ng/mL obtained within 90 days prior to registration
Patients must have a QTc interval < 461 msec on the 12 lead ECG within 42 days prior to registration. Patients with asymptomatic or incidental bundle branch blocks may have QTc measured by a cardiologist or standard formulas such as Bazett's or Fridericia's to adjust for pre-existing blocks
Patients must have adequate hepatic function, within 28 days prior to registration, as evidenced by: • bilirubin ≤ 2 x institutional upper limit of normal (ULN), and • SGOT (AST) and SGPT (ALT) ≤ 3 x institutional ULN, or ≤ 5 x institutional ULN if liver metastases are present
Patients must have adequate renal function, within 28 days prior to registration, as evidenced by calculated creatinine clearance ≥ 40 mL/min using a serum creatinine or by 24-hour urine creatinine (using Cockroft-Gault equation)
Patients must have adequate hematologic function, within 28 days prior to registration as evidenced by
leukocytes ≥ 3,000/mcL
absolute neutrophil count (ANC) ≥ 1,500/mcL
hemoglobin ≥ 9 g/dL, and
platelets ≥ 100,000/mcL
Patients must have a Zubrod performance status of 0-2. Zubrod performance status 3
No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for 5 years
will be allowed if from bone pain only
Patients must be ≥ 18 years of age
Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
Voluntary written informed consent must be obtained before performance of any study-related
procedure not part of normal medical care, with the understanding that consent may be
withdrawn by the patient at any time without prejudice to future medical care

Exclusion Criteria

Patients with known brain metastases are not eligible. Brain imaging studies are not
required for eligibility if the patient has no neurologic signs or symptoms suggestive
of brain metastasis. But, if brain imaging studies are performed, patients must be
negative for disease
Patients must not have received prior and/or must not have any plans for receiving
Patients must not be known to have hypersensitivity to abiraterone or to LHRH agonist
concomitant therapy with ketoconazole, aminoglutethimide, or enzalutamide (MDV3100)
Concurrent megestrol for hot flashes is allowed
Patients must not have received any prior cytotoxic chemotherapy for metastatic
prostate cancer. Prior cytotoxic chemotherapy with curative intent in the neoadjuvant
or adjuvant setting is allowed. At least 2 years must have elapsed since completion of
cytotoxic chemotherapy in the neoadjuvant and/or adjuvant setting
Patients must not have New York Heart Association Class III or IV heart failure at the
time of screening. Patients must not have any thromboembolic event, unstable angina
pectoris, myocardial infarction, or serious uncontrolled cardiac arrhythmia within 6
months prior to registration. (Note: Androgen deprivation therapy may prolong the
QT/QTc interval. Patients with congenital long AT syndrome, congestive heart failure
frequent electrolyte abnormalities, and patients taking drugs known to prolong the QT
interval may be at increased risk.)
Patients with a known history of primary and secondary adrenal insufficiency are not
eligible
Patients must not have known gastrointestinal (GI) disease or GI procedure that could
interfere with the GI absorption or tolerance of abiraterone, including difficulty
swallowing oral medications per investigator's clinical judgement
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