Last updated on July 2019

Cannabidiol Morphine Pain


Brief description of study

The purpose of the proposed study is to investigate the interaction of cannabidiol (CBD) and morphine effects on pain sensitivity. Cannabidiol is a cannabinoid (similar to cannabis, or marijuana) present in marijuana that alters some of the effects of marijuana.

Detailed Study Description

Eligible participants will be asked to participate in a total of three experimental sessions with each session day separated by at least one week. Each session day will last approximately 6-7 hours.

In the morning of each of the three study sessions participants will be asked to answer questions about how they feel and vital signs (blood pressure, heart rate, oxygen saturation, and temperature) will be measured using a non-invasive (external) vitals monitor.

Participants will be asked to take an oral morphine capsule.

Participants will participant in 3 smoking sessions where they will be asked to smoke cigarettes containing either cannabidiol or placebo (a blank).

Participant's response to different intensities of thermal (heat and cold) stimulation will be administered to test pain sensitivity.

Participants will be asked to complete questionnaires and have vital signs (blood pressure, heart rate) monitored.

After completing the third round of smoking and assessment battery, participants will be provided with lunch and can relax, watch television, listen to music or read.

Once vital signs and questionnaire ratings have returned to baseline levels, participants can leave the laboratory.

Clinical Study Identifier: NCT04030442

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Tolan Park Medical Building

Detroit, MI United States
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