Last updated on December 2018

Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation

Brief description of study

STUDY OBJECTIVES Primary objective(s) To evaluate the effect of macitentan 10 mg on pulmonary vascular resistance (PVR) as compared to placebo in subjects with pulmonary hypertension (PH) after left ventricular assist device (LVAD) implantation.

Secondary objectives To evaluate the effect of macitentan 10 mg as compared to placebo on cardio-pulmonary hemodynamics and disease severity in subjects with PH after LVAD implantation.

To evaluate the safety and tolerability of macitentan 10 mg in subjects with PH after LVAD implantation.

Exploratory objectives To explore the potential effect of macitentan 10 mg as compared to placebo on right ventricular function in subjects with PH after LVAD implantation.

To explore the potential effect of macitentan 10 mg as compared to placebo on selected clinical events in subjects with PH after LVAD implantation.

To explore the potential effect of macitentan 10 mg as compared to placebo on renal function as measured by glomerular filtration rate (GFR) in subjects with PH after LVAD implantation.

Clinical Study Identifier: NCT02554903

Contact Investigators or Research Sites near you

Start Over

Robert Scott, MD

#125_Mayo Clinic Arizona
Phoenix, AZ United States
  Connect »

Jennifer Cook, MD

#144_University of Arizona
Tucson, AZ United States
  Connect »

Jaime Moriguchi, MD

#106_Cedars-Sinai Medical Center
Beverly Hills, CA United States
  Connect »

Eric Adler, MD

#154_University of California San Diego
La Jolla, CA United States
  Connect »

John Chin, MD

#110_Sutter Heart Institute
Sacramento, CA United States
  Connect »

Munir Janmohamed, MD

#132_University of California San Francisco
San Francisco, CA United States
  Connect »

David Majure, MD

#123_MedStar Washington Hospital Center
Washington, WA United States
  Connect »

Scott Silvestry, MD

#126_Florida Hospital
Orlando, FL United States
  Connect »

Valluvan Jeevanandam, MD

#135_University of Chicago Medical Center
Chicago, IL United States
  Connect »

Antone Tatooles, MD

#113_Advocate Christ Medical Center
Oak Lawn, IL United States
  Connect »

Marco Caccamo, DO

#108_Indiana University Health Physicians Cardiology
Indianapolis, IN United States
  Connect »

Ashwin Ravichandran, MD

#112_St. Vincent Medical Group, Inc
Indianapolis, IN United States
  Connect »

Vladimir Cotarlan-Nistor, MD

#120_University of Iowa Hospitals and Clinics
Iowa City, IA United States
  Connect »

Maya Guglin, MD

#152_University of Kentucky
Lexington, KY United States
  Connect »

Emma Birks, MD

#117_University of Louisville
Louisville, KY United States
  Connect »

Stacy Mandra, MD

#105_Ochsner Medical Center
New Orleans, LA United States
  Connect »

Ryan Tedford, MD

#129_John Hopkins University Medical Center
Baltimore, MD United States
  Connect »

Amanda Vest, MD

#143_Tufts Medical Center
Boston, MA United States
  Connect »

Greg Lewis, MD

#138_Massachusetts General Hospital
Boston, MA United States
  Connect »

Michael Givertz, MD

#119_Brigham and Women's Hospital
Boston, MA United States
  Connect »

Mona Selej, MD

#115_Henry Ford Hospital
Detroit, MI United States
  Connect »

Robert Frantz, MD

#102_Mayo Clinic
Rochester, MN United States
  Connect »

Mark Everley, MD

#150_Saint Luke's Hospital
Kansas City, MO United States
  Connect »

Ronald Zolty, MD

#131_University of Nebraska Medical Center
Omaha, NE United States
  Connect »

Ulrich Jorde, MD

#133_Montefiore Medical Center
Bronx, NY United States
  Connect »

Evelyn Horn, MD

#103_Weill Cornell Medical College
New York, NY United States
  Connect »

Raymond Bietry, MD

#139_Icahn School of Medicine at Mount Sinai
New York, NY United States
  Connect »

Jean Elwing, MD

#148_University of Cincinnati Medical Center
Cincinnati, OH United States
  Connect »

Miriam Jacob, MD

#153_Cleveland Clinic
Cleveland, OH United States
  Connect »

Veronica Franco, MD

#101_The Ohio State University Wexner Medical Center
Columbus, OH United States
  Connect »

Mark Bonnell

#145_The University of Toledo Medical Center
Toledo, OH United States
  Connect »

Doug Horstmanshof, MD

#121_Integris Baptist Medical Center
Oklahoma City, OK United States
  Connect »

David Silber, MD

#142_Penn State Heart and Vascular Institute
Hershey, PA United States
  Connect »

Jeremy Mazurek, MD

#140_Hospital of the University of Pennsylvania
Philadelphia, PA United States
  Connect »

Richard Agarwal, MD

#134_Allegheny General Hospital
Pittsburgh, PA United States
  Connect »

Jeffery Teuteberg, MD

#130_University of Pittsburgh Medical Center
Pittsburgh, PA United States
  Connect »

Patrick J McCann, MD

#141_Palmetto Health / Palmetto Heart
Columbia, SC United States
  Connect »

Jawwad Yusuf, MD

#151_Stern Cardiovascular Foundation
Memphis, TN United States
  Connect »

Mary Keebler, MD

#146_Vanderbilt University Medical Center
Nashville, TN United States
  Connect »

Ernest Haeusslein, MD

#149_Seton Heart Institute
Austin, TX United States
  Connect »

Shelley Hall, MD

#136_Baylor Health - Baylor University Medical Center
Dallas, TX United States
  Connect »

Myung Park, MD

#107_Houston Methodist Hospital
Houston, TX United States
  Connect »

Chandra Kunavarapu, VM

#122_Advanced Heart Failure Clinic - HCM
San Antonio, TX United States
  Connect »

Edward Gilbert, MD

#127_The University of Utah
Salt Lake City, UT United States
  Connect »

Jamie Kennedy, MD

#114_University of Virginia
Charlottesville, VA United States
  Connect »

Shashank Desai, MD

#111_Inova Fairfax Hospital
Falls Church, VA United States
  Connect »

Melissa Smallfield, MD

#116_Virginia Commonwealth University (VCU) Medical Center
Richmond, VA United States
  Connect »

Shane LaRue, MD

#104_Washington University School of Medicine
Saint Louis, MO United States
  Connect »

Gregg Lanier, MD

#147_Westchester Medical Center
Valhalla, NY United States
  Connect »

Brian Houston

Medical University of South Carolina
Charleston, SC United States
  Connect »

Ravi Dhingra

#155_University of Wisconsin Hospital and Clinics
Madison, WI United States
  Connect »

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.