Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty

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    Mayo Clinic
Updated on 28 March 2021
total knee replacement


Researchers are trying to determine if knee pain can be reduced by proactively protecting the free end of the saphenous nerve versus leaving it in the standard position during total knee arthroplasty.


Subjects scheduled for total knee arthroplasty will be randomized to two arms. One arm will have the standard saphenous nerve neurectomy during their surgery. The other arm will have the same neurectomy procedure with the free end of the nerve tucked into soft tissue to protect the nerve ending.

Condition Knee Pain Chronic
Treatment Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty
Clinical Study IdentifierNCT04028947
SponsorMayo Clinic
Last Modified on28 March 2021


Yes No Not Sure

Inclusion Criteria

Primary unilateral total knee arthroplasty candidate

Exclusion Criteria

Body Mass Index (BMI) >40
Inflammatory arthritis
Unable to follow up visits (long distance from Mayo Clinic)
Poor compliance risk
Health condition deemed by physician to preclude patient's ability to participate in the trial
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