GAIN Trial – Alzheimer’s Disease Research Study mild to moderate

    Not Recruiting
  • End date
    Jan 31, 2022
Updated on 12 January 2021


The Memory Health Center at Summit Research Network, is enrolling participants in the GAIN clinical trial.  This trial will evaluate whether the investigational medication, COR388, is safe and can slow or stop the progression of Alzheimer’s by reducing the damage caused by a bacteria commonly associated with gum disease that can travel to the brain.



  • Study participation will last about a year.  
  • Following a screening period of up to 6 weeks, qualified participants will be randomly assigned to the oral investigational medication, C0R388, or a placebo (an inactive substance).  
  • During the treatment period, the participants will visit the research center 9 times over a 48 week period.  
  • All participants will come back 6 weeks after the final study visit for a follow-up visit.


Study-related neuro-psychological evaluation, neurological and physical exams, laboratory tests, ECG, and brain scans are provided to research study participants at designated time points during screening and throughout the trial. As with all studies at the Memory Health Center, if you qualify for this research study all research related care, evaluations, study medication, and office visits will be provided at no cost. Insurance is not required for study participation and compensation may be available.

Condition Dementia, Alzheimer's Disease
Clinical Study IdentifierTX226200
Last Modified on12 January 2021

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