Efficacy and Safety of Crinone Versus Combination Medication (ACCESS)

  • End date
    Dec 4, 2022
  • participants needed
  • sponsor
    Merck KGaA, Darmstadt, Germany
Updated on 16 July 2021
embryo transfer


The study to compare to the efficacy and safety of Crinone versus combination medication in infertile women receive frozen-thawed embryo transfer (FET) in artificial cycles (AC).

Condition Female Genital Diseases, Infertility, Gynecological Infections, sterility, unable to conceive
Treatment Crinone, Duphaston, Duphaston
Clinical Study IdentifierNCT03858049
SponsorMerck KGaA, Darmstadt, Germany
Last Modified on16 July 2021


Yes No Not Sure

Inclusion Criteria

Participants are eligible to be included in the study only if all the
following criteria
Participants who will receive artificial frozen-thawed embryo transfer (FET) cycle study interventions
Participants who have no more than two Day 5 embryos are planned to be transferred (follow the clinical practice of the study site)
Participants have received estradiol valerate for no more than 20 days
Participants have a transitional-endometrium of greater than or equal to 8 millimeter
Participants have normal uterine cavity
Participants can give signed informed consent
Participants are willing to follow the study protocol and able to complete the study

Exclusion Criteria

Participants are willing to follow the study protocol and able to complete the study
Participants with greater than or equal to three previously failed cycles of ET
Participants with diseases that cannot tolerate pregnancy
Severe endometriosis (Endometriosis American Society for Reproductive Medicine (ASRM) criteria from 1996)
Known hypersensitivity to progesterone, the excipients of Crinone and Duphaston Vaginal bleeding of unknown origin
History of recurrent miscarriages
Thromboembolic diseases (thrombophlebitis, thromboembolic disorder, or cerebral apoplexy) or participants with a history of these conditions
Known or suspected progestogen-dependent neoplasm
Participation in another clinical trial within the past 30 days
Contraindications of both Crinone and Duphaston
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note