Phenotyping Genetic Risk for Type 2 Diabetes

  • End date
    Jun 30, 2023
  • participants needed
  • sponsor
    University of Pennsylvania
Updated on 22 March 2022
impaired glucose tolerance
insulin resistance
Accepts healthy volunteers


This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.


The study team will recruit individuals based on genetic risk score for type 2 diabetes from the biobank populations who have agreed to be recontacted for future research. Each participant will undergo a frequently sampled four-hour oral glucose tolerance test and whole body DXA scan (dual-energy X-ray absorptiometry) in addition to baseline laboratory and history assessment.

Condition Diabetes Mellitus, Type 2, Genetics
Treatment 75g glucose beverage (Glucola, Trutol, or similar brand), DXA, whole body
Clinical Study IdentifierNCT04024631
SponsorUniversity of Pennsylvania
Last Modified on22 March 2022


Yes No Not Sure

Inclusion Criteria

Age 10-70 years
Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research
Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher

Exclusion Criteria

prior diagnosis of type 1, type 2, or secondary diabetes
use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
acute illness that may impact insulin and glucose dynamics
hypothalamic obesity or related genetic disorder of metabolism
recent systemic chemotherapy use
gastrointestinal impairment or surgery that may impact absorption
major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
inability to comply with study protocol
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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