Interest of Intravitreal Injections of Anti-VEGF as Initial and Adjuvant Treatment in Coats Disease (COATS-VEGF)

  • End date
    Nov 23, 2024
  • participants needed
  • sponsor
    Fondation Ophtalmologique Adolphe de Rothschild
Updated on 12 February 2022


Coats disease is a predominantly unilateral progressive retinal vascular disease, characterized by retinal telangiectasias with intra- or subretinal exudate deposits, which can lead to retinal detachment and one-sided blindness. Several treatment modalities are available and the choice of one of them depends on the stage of the disease and the habits of each center (laser photocoagulation, cryotherapy ...). VEGF (Vascular Endothelial Growth Factor) was found to be significantly elevated in the aqueous humor and subretinal fluid of patients with Coats disease. Several studies have shown the potential efficacy of intra-vitreous injections of anti-VEGF. But the results on their effectiveness have been evaluated only on small series of patients. Most published studies have analyzed their efficacy combined with another treatment, mainly laser photocoagulation. The true efficacy of anti-VEGF therapy as initial therapy, and then combined in Coats disease remains unknown. Currently, several centers are initiating first-line anti-VEGF injections, although no rigorous evaluation of this therapeutic strategy has been conducted.

The identification of the best treatment regimen will allow in the future the reduction of laser reprocessing and will ensure a better functional benefit in the affected patients.

Condition Retinal Telangiectasis, Coats Disease
Treatment Laser, Anti-VEGF injections of bevacizumab
Clinical Study IdentifierNCT03940690
SponsorFondation Ophtalmologique Adolphe de Rothschild
Last Modified on12 February 2022


Yes No Not Sure

Inclusion Criteria

Coats disease confirmed by fundus examination and fluorescein angiography
Stage 2 or 3 at the fundus (Shields classification)
Naive to any eye treatment on the eye affected by Coats disease

Exclusion Criteria

Other ocular pathology on the eye affected by Coats' disease
Bilateral forms of the disease
History of hypersensitivity to bevacizumab
History of hypersensitivity to products of Chinese hamster ovary cells or other recombinant human or humanized antibodies
Allergic reaction in a previous fluorescein retinal angiogram
Pregnancy or breastfeeding
Active or suspected periocular infection
Contraindication to treatments used for general anesthesia and morphine derivatives
Cardiovascular, haemorrhagic and gastrointestinal risks
Premature baby who has not reached the correct age of 37 weeks
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note