Study of Niraparib With Radiotherapy for Treatment of Metastatic Invasive Carcinoma of the Cervix (NIVIX)

  • STATUS
    Recruiting
  • End date
    Mar 2, 2026
  • participants needed
    24
  • sponsor
    Michelle S Ludwig
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Updated on 10 May 2022
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Summary

The most effective strategy for managing distantly metastatic invasive carcinomas of the cervix is not defined. Based on the success of niraparib in breast and ovarian cancer trials and the concern for toxicities and comorbidities limiting the compliance of concurrent cisplatin for cervical cancer, this study is a phase I/II study of women diagnosed with distantly metastatic (Stage IV) disease to determine the maximum tolerated dose and to evaluate the safety, tolerability and preliminary efficacy of niraparib, an orally available small molecule PARP inhibitor when administered concurrently with definitive regional radiotherapy for treatment of cervical cancer. Women enrolled in this study will receive 3-6 cycles of induction-style carboplatin and paclitaxel followed by definitive doses of pelvic radiotherapy along with the oral niraparib given at the same time.

Details
Condition Metastatic Carcinoma of the Cervix
Treatment Nirapaib
Clinical Study IdentifierNCT03644342
SponsorMichelle S Ludwig
Last Modified on10 May 2022

Eligibility

 Yes No Not Sure

Inclusion Criteria

Participant must have histologically confirmed diagnosis of invasive squamous cell or adenocarcinoma of the cervix, FIGO Stage IIIC2 or IV (see Appendix 5 of the currently approved protocol)
Participant must have an Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1
Participant must be ≥ 18 years of age
Participant must have adequate organ function within 28 days of registration, defined as follows
Absolute neutrophil count ≥ 1,500/µL
Platelets ≥ 100,000/µL
Hemoglobin ≥ 9 g/dL
Serum creatinine ≤ 1.5 x upper limit of normal (ULN) or calculated creatinine clearance ≥ 30 mL/min using the Cockcroft-Gault equation
Total bilirubin ≤ 1.5 x ULN (≤2.0 in patients with known Gilberts syndrome) OR direct bilirubin ≤ 1 x ULN
Aspartate aminotransferase and alanine aminotransferase ≤ 2.5 x ULN unless liver metastases are present, in which case they must be ≤ 5 x ULN
Participant receiving corticosteroids may continue as long as their dose is stable for
Participant must agree to not donate blood during the study or for 90 days after the last dose of study treatment
least 4 weeks prior to initiating protocol therapy
Female participant of childbearing potential must have a negative serum pregnancy test within 14 days prior to registration. Pregnancy test should be repeated within 7 days before CT simulation if more than 14 days has passed since the previous pregnancy test. (If serum test is falsely positive, pregnancy can be excluded by appropriate pelvic imaging.) Patient must agree to abstain from activities that could result in pregnancy from screening through completion of 7 days of pelvic radiotherapy. Females of non-childbearing potential is defined as follows (by other than medical reasons)
≥45 years of age and has not had menses for >1 year
Post-hysterectomy, post-bilateral oophorectomy, post external beam radiation of 6 Gy to the pelvis, or post-tubal ligation. Documented hysterectomy or oophorectomy must be confirmed with medical records of the actual procedure or confirmed by a physical exam or imaging
Participant must agree to not breastfeed during the study and for 180 days after the
Participant must be able to understand the study procedures and agree to participate in the study by providing written informed consent
last dose of study treatment
Participant must have completed 3-6 cycles of platinum based chemotherapy (acceptable regimens in Appendix 7) with clinical evidence of CR (complete response) or PR (partial response) by RECIST criteria no less than 4 weeks and no greater than 12 weeks prior to initiation of protocol therapy. If bevacizumab used, 6 weeks must elapse between administration of bevacizumab and start of radiation therapy
Participant must be eligible for chemoradiation treatment in the opinion of the treating investigator
Participants who are HIV+ must have CD4 counts >200/dL and demonstrate documented HAART compliance
Chemotherapy-related hematological toxicities must have resolved to Grade 1 or less
Participant must have had a CT (chest/abdomen/pelvis) or PET-CT, within 56 days of registration

Exclusion Criteria

Participant must not be simultaneously enrolled in any interventional clinical trial
Participant must not have known documented intra-uterine pregnancy
Participant must not have had major surgery ≤ 3 weeks prior to initiating protocol therapy and participant must have recovered from any surgical effects
Participant must not receive any additional chemotherapy while on study
Participant must not have received investigational therapy ≤ 4 weeks, or within a time interval less than at least 5 half-lives of the investigational agent, whichever is shorter, prior to initiating protocol therapy. Participant that has received prior treatment with a PARP inhibitor is excluded from this study
Participant has had radiation therapy encompassing >20% of the bone marrow within 2 weeks; or any radiation therapy within 1 week prior to Day 1 of protocol therapy
Participant last treatment with platinum based chemotherapy was ≥12 weeks from initiation of protocol therapy
Participant must not have a known hypersensitivity to niraparib components or excipients
Participant must not have received colony stimulating factors (e.g. granulocyte colony-stimulating factor, granulocyte macrophage colony stimulating factor, or recombinant erythropoietin) within 4 weeks prior to initiating protocol therapy
Participant must not have any known history of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML)
Participant must not have a serious, uncontrolled medical disorder, nonmalignant systemic disease, or active, uncontrolled infection. Examples include, but are not limited to, uncontrolled ventricular arrhythmia, NYHA Class III/IV heart failure, recent (within 90 days) myocardial infarction, uncontrolled major seizure disorder, or any psychiatric disorder that prohibits obtaining informed consent. Participant must not have had a CVA within 6 months of registration
Participant must not have had diagnosis, detection, or treatment of another type of cancer ≤ 2 years prior to initiating protocol therapy (except basal or squamous cell carcinoma of the skin that has been definitively treated)
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