Improved Prediction of Recurrent Stroke and Detection of Small Volume Stroke

  • STATUS
    Recruiting
  • End date
    Mar 23, 2023
  • participants needed
    720
  • sponsor
    UMC Utrecht
Updated on 10 October 2021
ct scan
clot
stroke
ischemia
arterial occlusion
acute stroke
transient ischemic attack
diffusion weighted imaging

Summary

Rationale: Over 20.000 people suffer an ischemic stroke in the Netherlands each year. Large artery occlusions are easy to identify and can be treated with endovascular clot removal. 70% of patient will however suffer from a more distal occlusion resulting in small volume stroke or a transient ischemic attack (TIA). Small ischemic lesions are hard to detect with current acute stroke protocols. TIA and small volume stroke patients, are at an increased risk for recurrent stroke, making immediate diagnosis critical. Because thrombo-embolic sources often cause these strokes, identifying and treating the underlying aetiology has the potential to radically lower the risk of recurrence and improve the outcome of these patients.

Objectives: 1) To identify clinical and imaging predictors of recurrent stroke; 2) To improve early detection of small volume stroke with admission computed tomography perfusion (CTP) in patients with suspected acute ischemic stroke with small volume stroke or no ischemia on admission imaging.

Study design: Prospective, multicenter cohort study.

Study population: All patients who visited the University Medical Center (UMC) Utrecht, the Amsterdam University Medical Centers (Amsterdam UMC), location Academic Medical Center (AMC) or the St. Antonius Hospital and who underwent a CT-scan of the brain within 9 hours after onset of stroke symptoms with an age 18 years. Within 36 months, 720 patients will be enrolled in the study. Of these patients, 300 patients will be included for the follow-up magnetic resonance imaging (MRI).

Main study parameters/endpoints: The main study endpoints are: 1) Stroke recurrence rate at 2 years; 2) Presence and volume of acute ischemic lesions on follow-up diffusion weighted imaging MRI.

Details
Condition Ischemic Stroke
Clinical Study IdentifierNCT04019483
SponsorUMC Utrecht
Last Modified on10 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years
Time from symptom onset until imaging is <9 hours
Clinical diagnosis of acute ischemic stroke or TIA
Informed consent from patient or family after the admission scan (unless the patient died)
Patients who awaken with stroke symptoms can only be included if they went to sleep without any stroke symptoms and the time from going to sleep until imaging is less than 9 hours

Exclusion Criteria

Patients with another diagnosis such as intracerebral hemorrhage, subarachnoid hemorrhage or tumor
Patients with known contrast allergy or renal failure
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