Neurobehavioral Mechanisms of Choice in Opioid Use Disorder

  • participants needed
  • sponsor
    Joshua A. Lile, Ph.D.
Updated on 12 September 2023
narcotic use
opioid withdrawal


The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and neurobiological processes underlying abnormal task performance. A second objective is to identify an appropriate dose of intravenous remifentanil for subsequent studies in physically dependent individuals with opioid use disorder.

Condition Opioid Use Disorder
Treatment Remifentanil, Oxycodone
Clinical Study IdentifierNCT03958474
SponsorJoshua A. Lile, Ph.D.
Last Modified on12 September 2023

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