Benefit of a Flash Dose of Corticosteroids in Digestive Surgical Oncology: a Randomized, Double Blind, Placebo-controlled Trial (CORTIFRENCH)

  • End date
    Sep 15, 2026
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire Dijon
Updated on 15 March 2022


Perioperative inflammation is harmful in cancer patients, namely in those undergoing surgery: it increases the risk of recurrence, decreases cancer survival, increases post-operative complications, and prolongs the time of recovery and the duration of hospital stay. Severe postoperative complications are also a risk factor of poor survival in cancer patients. Seemingly, some effective therapies currently used to improve the surgical outcome (e.g. immunonutrition, enhanced-recovery protocols) have an inflammatory effect. The modulation of perioperative inflammation therefore seems crucial to improve outcomes in patients undergoing surgery for digestive cancer.

A short perioperative treatment with high doses of corticosteroids has already been tested in several randomized trials. A recent meta-analysis showed that perioperative corticosteroids decreased inflammatory markers and might be associated with fewer complications in esophageal, liver, pancreatic and colorectal surgery: the decrease in the risk of postoperative complications was around 50% without adverse effects.

Condition Elective Surgery for Any Digestive Cancer
Treatment blood samples, Injection of methylprednisolone, Injection of sodium chloride
Clinical Study IdentifierNCT03875690
SponsorCentre Hospitalier Universitaire Dijon
Last Modified on15 March 2022


Yes No Not Sure

Inclusion Criteria

Age >_18 years
Elective surgery for any digestive cancer (except purely hepatic surgery)
Patients operated in a curative intent
Patients who had given their written informed consent
Patients affiliated to a National health insurance scheme

Exclusion Criteria

Emergency surgery
Pregnant or breastfeeding women
Patients with an ongoing oral treatment by steroids
Palliative surgery
Exclusive liver surgery
Concomitant hyperthermic intraperitoneal chemotherapy
Patient with at least one contra-indication to methylprednisolone treatment
active infection
on course viral disease (particularly hepatitis, herpes, chickenpox, herpes zoster)
uncontrolled psychotic state
hypersensitivity to methylprednisolone or to one of its excipients
ASA grade >3
Persons subject to a measure of legal protection (guardianship, tutorship)
Persons subject to a court order
Impossibility to adhere to the medical follow-up of the trial for geographical, social or psychological reasons
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note