Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression

    Not Recruiting
  • participants needed
  • sponsor
    The University of Texas Health Science Center, Houston
Updated on 14 June 2021
depressed mood
depressive episode
perinatal depression


Postpartum depression is a non-psychotic major or minor depressive episode that occurs during pregnancy or within 12 months of post-partum period. The nature of symptoms is same as depressive episode characterized by depressed mood, anxiety, sleep difficulties, suicidal thoughts, tiredness and diminished interest in pleasurable activities. Severe maternal depression affects children by increasing the risk of emotional and behavioral and physical health problems and cognitive difficulties. Thus early screening and intervention is critical in reducing the negative impact of PND in the mother and child, family and the community.

The purpose of this study is to assess the safety, pharmacokinetics and antidepressant efficacy of sub-anesthetic dose of intravenous ketamine in perinatal depression.

Condition Postpartum depression
Treatment Ketamine 0.5 mg/kg, Ketamine 0.2 mg/kg
Clinical Study IdentifierNCT04011592
SponsorThe University of Texas Health Science Center, Houston
Last Modified on14 June 2021

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