Last updated on September 2020

Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Postpartum depression
  • Age: Between 18 - 45 Years
  • Gender: Female

Inclusion Criteria:

  • Female subjects, ages 18-45 years
  • Experienced a major depressive episode in the postpartum period beginning within the first 4 weeks following delivery and with moderate or severe symptoms (>12 EPDS or >14 HAM-D).
  • No or partial response to adequate doses of SSRI medications to treat PND for longer than 6 weeks.
  • PND patients will be requested to maintain the stable dose of antidepressants while enrolled in the study trial.
  • Patients that can speak and read the English language, are able to understand the study procedures and sign the informed consent

Exclusion Criteria:

  • No current or past psychosis or severe personality disorder.
  • No current substance abuse or dependence.
  • No serious and imminent suicidal or homicidal risk.
  • No recent or history of major and unstable medical problems that affect brain anatomy, neurochemistry, or function.
  • Not diagnosed with cardiovascular disorders.
  • No increased risk of laryngospasm or active upper respiratory infections.
  • Not diagnosed with an intellectual disability or neurodegenerative diseases.
  • Mothers that are currently breastfeeding.
  • No current pregnancy.

Recruitment Status: Closed


Brief Description Eligibility Contact Research Team


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