Last updated on November 2019

Rostock International Parkinson's Disease Study (ROPAD)


Brief description of study

Parkinson's disease (PD) is one of the most common neurodegenerative disorders worldwide, affecting approximately 1% of individuals older than 60 years and causes progressive disability.

PD is mostly considered as idiopathic disease, however more and more data suggest that it is a disease that involves interaction of genetic and environmental factors. The most common monogenic form and the one most closely resembling idiopathic PD is LRRK2 (Leucine-rich repeat kinase 2 gene) associated PD.

The aims of this study are the identification of 1,500 LRRK2-positive patients, the identification of 1,500 non-LRRK2 PD patients (including a subset of ~500 patients with monogenic PD patients other than LRRK2) and the establishment of a candidate biomarker in the LRRK2-positive cohort.

Clinical Study Identifier: NCT03866603

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