Last updated on July 2019

The Hemodynamics Effect of Levcromakalim After Glibenclamide Administration Assessed by High Resolution Magnetic Resonance Angiography (MRA) Technique in a Randomized Double-blind Cross-over Placebo-controlled Study With Healthy Volunteers


Brief description of study

To investigate the effect of levcromakalim/placebo infusion on cranial arteries after glibenclamide administration.

Detailed Study Description

12 healthy participants will randomly be allocated to receive levcromakalim or placebo on to different days efter oral glibenclamide administration.

The aim of the study is to investigate the effect of levcromakalim/placebo infusion on cranial arteries after glibenclamide administration.

Repeated magnetic resonance angiography (MRA) measurements covering the middle meningeal artery (MMA), superficiel temporal artery (STA) and middle cerebral artery (MCA) before and after glibenclamide administration and levcromakalim/placebo infusion.

Clinical Study Identifier: NCT03886922

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