Last updated on July 2019

Sleep for Stroke Management and Recovery Trial


Brief description of study

The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.

Detailed Study Description

Sleep SMART has a prospective, randomized, open-label, blinded-endpoint (PROBE) design. It is a multi-site, parallel-group superiority trial that compares 6 months of OSA treatment to usual care. The study includes two trials: a prevention study with an embedded recovery trial. 3062 subjects will be randomized over 5 years at 110 sites within the NINDS-funded StrokeNet clinical trials network.

Clinical Study Identifier: NCT03812653

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University of Alabama Hospital

Birmingham, AL United States
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Mercy San Juan Medical Center

Carmichael, CA United States
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UCSD Health La Jolla

La Jolla, CA United States
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Cedars-Sinai Medical Center

Los Angeles, CA United States
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Hoag Memorial Hospital Presbyterian,

Newport Beach, CA United States
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Pasadena, CA United States
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New Haven, CT United States
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UF Health Shands Hospital

Gainesville, FL United States
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Brooks Rehabilitation Hospital

Jacksonville, FL United States
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Sarasota Memorial Hospital

Sarasota, FL United States
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Grady Memorial Hospital

Atlanta, GA United States
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University of Chicago

Chicago, IL United States
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St. Luke's Methodist Hospital

Cedar Rapids, IA United States
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St Elizabeth Healthcare NKY

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University Health Shreveport

Shreveport, LA United States
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Boston Medical Center

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Detroit Receiving Hospital

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Henry Ford Hospital

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Butterworth Hospital

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Minneapolis, MN United States
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Mayo Clinic Saint Marys Campus

Rochester, MN United States
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United Hospital

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Saint Louis, MO United States
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Maimonides Medical Center

Brooklyn, NY United States
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Asheville, NC United States
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Winston-Salem, NC United States
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Christ Hospital

Cincinnati, OH United States
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UH Cleveland Medical Center

Cleveland, OH United States
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Cleveland Clinic

Cleveland, OH United States
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OSU Wexner Medical Center

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West Chester, OH United States
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Abington, PA United States
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Temple University Hospital

Philadelphia, PA United States
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Columbia, SC United States
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Greenville, SC United States
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Valley Baptist Medical Center

Harlingen, TX United States
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Salt Lake City, UT United States
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Charlottesville, VA United States
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Seattle, WA United States
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Ruby Memorial Hospital

Morgantown, WV United States
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Medical College of Wisconsin

Milwaukee, WI United States
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