Combination of Toripalimab and Chemoradiotherapy in Esophageal Cancer

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    42
  • sponsor
    Mian XI
Updated on 28 March 2021

Summary

Definitive chemoradiotherapy (CRT) is the standard treatment option for unresectable esophageal cancer (EC). However, as high as more than 40% of EC patients experienced locoregional recurrence after concurrent CRT. Immunotherapy targeting the PD-1/PD-L1 checkpoints has demonstrated promising activity in advanced EC. The aim of this study was to evaluate the efficacy and safety of the combination of toripalimab (an anti-PD-1 antibody) combined with definitive CRT in locally advanced esophageal squamous cell carcinoma (ESCC).

Details
Condition Unresectable Esophageal Cancer
Treatment Intensity-modulated radiotherapy, Toripalimab, Paclitaxel/cisplatin
Clinical Study IdentifierNCT04005170
SponsorMian XI
Last Modified on28 March 2021

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