Stress Response in Opioid Use Disorder

  • STATUS
    Recruiting
  • days left to enroll
    20
  • participants needed
    120
  • sponsor
    Mclean Hospital
Updated on 4 June 2022

Summary

Opioid use disorder is a major public health problem. Although there are effective treatments for this disorder, many people still relapse and thus there is a need for new treatments to improve outcomes. People who have a strong emotional and physical response to stress are at a higher risk of relapse. The goal of this project is to test the effect of strategies to reduce response to stress in people diagnosed with opioid use disorder. Men and women diagnosed with opioid use disorder will be recruited for a one-session study. Participants will be randomly assigned to one of three brief instructional conditions followed by a brief laboratory stress test. Investigators hypothesize that, compared to education about stress, brief strategies to help people cope with negative emotions will reduce responses to stress and increase tolerance of stress. If this hypothesis is supported, it will inform the development of new treatments to improve outcome in opioid use disorder.

Details
Condition Opioid-use Disorder
Treatment Psychoeducational Control, Affect Regulation, Affect Labelling
Clinical Study IdentifierNCT03616379
SponsorMclean Hospital
Last Modified on4 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

years or older
primary diagnosis of opioid use disorder
ability to read and provide informed consent

Exclusion Criteria

major psychiatric or medical condition that would interfere with the ability to complete study procedures
current opioid withdrawal
presence of another current substance use disorder at a severity requiring acute treatment
endocrine disease or current steroid prescription
opioid-positive urine drug screen or breath alcohol test on the data or enrollment (not including prescribed medications)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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