Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study
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- STATUS
- Recruiting
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- End date
- May 31, 2023
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- participants needed
- 800
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- sponsor
- First Affiliated Hospital of Guangxi Medical University
Summary
The only curative therapy for thalassemia major remains the replacement of the defective erythropoiesis by allogeneic hematopoietic stem cell transplantation(allo-HSCT). We conduct a prospective multicenter study to evaluate the efficacy of allo-HSCT in the treatment of thalassemia major.
Description
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the established curative option for thalassemia major (TM). Previous study has predicted that more than 90% of TM patients can survive after allo-HSCT with a thalassemia-free survival (TFS) in around 80% of them.The purpose of this study is to evaluate the efficacy of allo-HSCT in the treatment of thalassemia major.
Details
| Condition | Thalassemia Major |
|---|---|
| Treatment | cyclophosphamide, methotrexate, mycophenolate mofetil, busulfan, Fludarabine, Tacrolimus, Ruxolitinib, Thymoglobulin, Basiliximab, Cyclosporine A |
| Clinical Study Identifier | NCT04009525 |
| Sponsor | First Affiliated Hospital of Guangxi Medical University |
| Last Modified on | 11 February 2022 |
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