Last updated on July 2019

Comparison of Lindioil (Indigo Naturalis Oil Extract) Ointment to Protopic Ointment 0.1% in Treating Atopic Dermatitis


Brief description of study

The aims of this study are:

  1. Compare the efficacy of Lindioil ointment and Protopic ointment in treating atopic dermatitis.
  2. Compare the safety of Lindioil ointment and Protopic ointment in treating atopic dermatitis.
  3. Compare the time to relapse after ceasing of treatment of Lindioil ointment and Protopic ointment.
  4. Compare the change of skin microbiome before and after Lindioil ointment and Protopic ointment treatment.

Detailed Study Description

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by itchiness. Topical corticosteroids are typically used to treat AD. However, many patients have concerns about the safety of long-term use, and seek alternative therapies such as traditional Chinese medicine (TCM). In TCM, indigo naturalis has been used to treat various infectious and inflammatory skin diseases for hundreds of years. The investigate also found that the results of indigo naturalis ointment treatment in other trial were comparable to the results of calcineurin inhibitor (such as Tacrolimus) treatment, and would like to verify this assertion. The aim of this study is to compare the efficacy of Lindioil ointment with that of Protopic (Tacrolimus ointment 0.1%) in treating AD.

Clinical Study Identifier: NCT03614221

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