Platelet Rich Plasma and Recurrent Implantation Failure

  • End date
    Nov 20, 2022
  • participants needed
  • sponsor
    Royan Institute
Updated on 1 May 2021


This study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with recurrent implantation failure. The study population consisted of infertile women with a history of recurrent implantation failure who had failed to achieve a clinical pregnancy which at least four good quality embryos transfers and are now candidate for IVF-ICSI or freeze embryo transfer cycles with and without intra uterine infusion of platelet rich plasma in Reproductive Biomedicine Research Center, Royan institute, Tehran Iran.


Platelet Rich Plasma (PRP) is a blood product with a high platelet and a normal plasma fibrinogen level. Given the effective factors of RPR in repairing damaged tissues, its application in the field of regenerative medicine has widely been interested over the last three decades. According to the literature, PRP is an effective and safe treatment in the fields of orthopaedics, dermatology, ophthalmology, and repair of neurological, vascular, and connective tissue damage, but its application in the field of infertility is limited to a few pilot studies in which the effects of PRP on endometrium and recurrent implantation failure (RIF) were investigated. Given the importance of endometrial compliance and according to molecular studies, which indicate that endometrial growth factors in women with a history of RIF are lower than normal fertile women, PRP, along with other existing strategies, can be used to improve endometrial compliance in patients with a history of RIF. The present randomized, controlled clinical trial is proposed to determine the efficacy of PRP in the treatment of patients with RIF in the cycles of IVF-ICSI and frozen embryo transfer at Royan Institute.

Condition Recurrent Implantation Failure
Treatment Intra uterine infusion of platelet rich plasma
Clinical Study IdentifierNCT03996837
SponsorRoyan Institute
Last Modified on1 May 2021


Yes No Not Sure

Inclusion Criteria

Infertile women with a history of recurrent implantation failure who had failed to achieve a clinical pregnancy which at least four good quality embryos transfers
Non endocrine, hematologic and autoimmune disorders
Non chromosomal and genetic abnormalities
Non uterine anomalies, surgical history, endometriosis, adenomyosis, hydro salpinx, uterine fibroids, Polycystic ovary syndrome
Having at least three good quality embryos

Exclusion Criteria

Recent fever condition
Use of corticosteroids (in up to 2 weeks before the procedure) or non-steroid anti-inflammatories (in up to 48 hours before procedure)
Anemia, thrombocytopenia, platelet dysfunction syndrome, hypofibrinogenemia
Septicemia, active infections with Pseudomonas, Klebsiella or Enterococcus
History of cancer
Patient's tendency for withdrawal
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