Last updated on August 2019

Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan


Brief description of study

Chronic obstructive pulmonary disease (COPD) is a common, preventable and treatable disease characterized by increasing airflow obstruction and the progressive development of respiratory symptoms including chronic cough, increased sputum production, dyspnea, and wheezing. The purpose of this prospective, epidemiological, cohort study is to evaluate the etiology of AECOPD in a Japanese population for comparison with observations in studies conducted in the United States of America and Europe. This study will support a precision medicine approach to COPD by estimating the proportion of bacterial, viral, eosinophilic and pauci-inflammatory exacerbations experienced by subjects and by comparing the lung microbiome, including the presence of potentially pathogenic viruses and bacteria, in stable-state COPD and during an AECOPD.

Clinical Study Identifier: NCT03957577

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