Evaluation of Splenic Metabolic Activity With 18FDG-PET in Hypertension

  • End date
    Sep 24, 2023
  • participants needed
  • sponsor
    Neuromed IRCCS
Updated on 24 April 2022
myocardial infarction
Accepts healthy volunteers


The purpose of this study is to evaluate the splenic activation in hypertensive patients, as compared to normotensives, using FDG-PET/CT imaging. Moreover, the investigators will investigate whether the splenic metabolic activity relates to the expression of circulating inflammatory proteins (high-sensitivity C-reactive protein [hsCRP]), interleukin-1b (IL-1b), tumor necrosis factor-a (TNF-a) or to immune profiles of activated T cells.

Condition Hypertension
Treatment PET/CT scan
Clinical Study IdentifierNCT02572765
SponsorNeuromed IRCCS
Last Modified on24 April 2022


Yes No Not Sure

Inclusion Criteria

absence of prior cancer diagnosis or remission from cancer at the time of FDG-PET/CT imaging (from at least 6 months)
age ≥ 30 and ≤ 85 years
absence of acute cardio/cerebrovascular disease (myocardial infarction, stroke, transient ischemic attack, revascularization)
absence of acute or chronic inflammatory or autoimmune disease
diagnosis of presence/absence of hypertension, on the basis of documented medical history

Exclusion Criteria

atrial fibrillation
use of anti-inflammatory drugs in the week preceding the FDG-PET/CT imaging
chronic use of anti-inflammatory drugs
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