The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer

  • End date
    Jan 28, 2024
  • participants needed
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 4 October 2022
surgery for prostate cancer


The purpose of this study is to determine if there is a difference in intra-abdominal pressure which surgeons use during surgery and post-surgery pain in men who undergo robotic prostate surgery with deep neuromuscular blockade (NMB), compared with moderate NMB.

Condition Prostate Cancer
Treatment Rocuronium 0.3mg/kg/hr, Rocuronium 1.5mg/kg/hr
Clinical Study IdentifierNCT03808077
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Adult patients under the age of 80
American Society of Anesthesiologists Physical Status 1, 2, 3
Elective Robotic Prostatectomy
Patient undergoing surgery at Josie Robertson Surgical Center

Exclusion Criteria

Age younger than 18
Inability to provide informed consent
Allergy to rocuronium, sugammadex, midazolam, propofol, fentanyl, lidocaine, mannitol (IV Acetaeminophen), IV Acetaminophen, Ketorolac, Morphine, Hydromorphone, Dexamethasone, Zofran, Benadryl, Compazine
Neuromuscular disease
Any patient with previous abdominal surgery less than or equal to 20 years prior to scheduled surgery date
Patients with BMI>35
Severe renal impairment (Creatinine clearance < 30 ml/min)
Patient receiving Toremifene or any history of receiving Toremifene
Chronic pain patients
Patients receiving suboxone
Patients receiving succinylcholine
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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