The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer

  • STATUS
    Recruiting
  • End date
    Jan 28, 2024
  • participants needed
    130
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 4 October 2022
prostatectomy
surgery for prostate cancer

Summary

The purpose of this study is to determine if there is a difference in intra-abdominal pressure which surgeons use during surgery and post-surgery pain in men who undergo robotic prostate surgery with deep neuromuscular blockade (NMB), compared with moderate NMB.

Details
Condition Prostate Cancer
Treatment Rocuronium 0.3mg/kg/hr, Rocuronium 1.5mg/kg/hr
Clinical Study IdentifierNCT03808077
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on4 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patients under the age of 80
American Society of Anesthesiologists Physical Status 1, 2, 3
Elective Robotic Prostatectomy
Patient undergoing surgery at Josie Robertson Surgical Center

Exclusion Criteria

Age younger than 18
Inability to provide informed consent
Allergy to rocuronium, sugammadex, midazolam, propofol, fentanyl, lidocaine, mannitol (IV Acetaeminophen), IV Acetaminophen, Ketorolac, Morphine, Hydromorphone, Dexamethasone, Zofran, Benadryl, Compazine
Neuromuscular disease
Any patient with previous abdominal surgery less than or equal to 20 years prior to scheduled surgery date
Patients with BMI>35
Severe renal impairment (Creatinine clearance < 30 ml/min)
Patient receiving Toremifene or any history of receiving Toremifene
Chronic pain patients
Patients receiving suboxone
Patients receiving succinylcholine
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