Methods of Computed Tomography Screening and Management of Lung Cancer

  • STATUS
    Recruiting
  • days left to enroll
    88
  • participants needed
    4000
  • sponsor
    Tianjin Medical University Cancer Institute and Hospital
Updated on 10 February 2022
ct scan
cancer
lung cancer
lung cancer screening
lung carcinoma
Accepts healthy volunteers

Summary

European lung cancer screening studies using computed tomography (CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time (VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.

Description

In this population-based study, participants will undergo a low-dose chest CT scan for two rounds. At baseline, the first CT scan will be performed in all participants and their data will be collected. One-year after the baseline, a second CT scan will be performed and data will be collected again. CT images of each participant will be read twice independently by two groups of readers after the baseline and 1-year follow-up scans. In the first reading, the detected lung nodules are evaluated for diameter and managed according to a routine diameter-based protocol. The clinical management of participants are based on the first reading. In the second reading, each scan will be interpreted again by radiologists, blinded to the first reading. Semi-automated volumetry software will be used. The lung nodules will be evaluated for volume and management will be simulated according to a European volume-based protocol. Participants will be followed up and any diagnosis of lung cancer and related information will be collected at the fourth year through the hospital information system and by contacting the participants or their relatives.

Details
Condition Lung Neoplasms, Computed Tomography, Mass Screening, Lung Nodules
Treatment lung cancer screening, lung cancer screening
Clinical Study IdentifierNCT03992833
SponsorTianjin Medical University Cancer Institute and Hospital
Last Modified on10 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Aged 40-74 years
Resident in the Hexi district of Tianjin city for at least 3 years
Having no self-reported history of any malignant tumor

Exclusion Criteria

Pregnant woman will be excluded
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