This is a prospective study comparing 4 groups: (1) non-smoking controls, (2) smokers without chronic obstructive pulmonary disease (COPD), (3) smokers with COPD, (4) severe asthma.
Bronchial biopsy specimens from each subject will be obtained to produce air-liquid-interface cell cultures. These will then be used to make observations concerning cilia and mucus rheology.
This is a first pilot study. The working hypothesis is that the largest group differences will be found for cilia densities; the latter metric was thus chosen as a primary criterion.
| Condition | Pulmonary Disease, Chronic Obstructive, Asthma, Smoking |
|---|---|
| Treatment | Bronchial biopsy, ALI culture |
| Clinical Study Identifier | NCT03187860 |
| Sponsor | University Hospital, Montpellier |
| Last Modified on | 6 July 2022 |
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