Ciliation and Mucus Rheology Parameters Determined Via Air-liquid-interface Cell Cultures in Non-smoking, Smoking, COPD and Asthmatic Patients (RhéMuc)

  • STATUS
    Recruiting
  • participants needed
    40
  • sponsor
    University Hospital, Montpellier
Updated on 6 July 2022
COPD
pulmonary disease
asthma
forced expiratory volume
spirometry
respiratory disorder
obstructive lung disease

Summary

This is a prospective study comparing 4 groups: (1) non-smoking controls, (2) smokers without chronic obstructive pulmonary disease (COPD), (3) smokers with COPD, (4) severe asthma.

Bronchial biopsy specimens from each subject will be obtained to produce air-liquid-interface cell cultures. These will then be used to make observations concerning cilia and mucus rheology.

This is a first pilot study. The working hypothesis is that the largest group differences will be found for cilia densities; the latter metric was thus chosen as a primary criterion.

Details
Condition Pulmonary Disease, Chronic Obstructive, Asthma, Smoking
Treatment Bronchial biopsy, ALI culture
Clinical Study IdentifierNCT03187860
SponsorUniversity Hospital, Montpellier
Last Modified on6 July 2022

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