Exercise Treatment With Standard Therapy for Metastatic Breast Cancer

  • End date
    Aug 1, 2023
  • participants needed
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 20 July 2022


This study will test any good and bad effects of aerobic exercise performed while you are receiving the usual first-line treatment for metastatic breast cancer. The researchers think that exercise helps delay the development of resistance to hormone therapy while slowing the growth of tumors.

Condition Hormone Receptor Positive Metastatic Breast Cancer
Treatment Exercise treatment
Clinical Study IdentifierNCT03988595
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on20 July 2022


Yes No Not Sure

Inclusion Criteria

Patients with histologically-confirmed, HR-positive (ER and/or PR), HER2-negative metastatic breast cancer (MBC)
Postmenopausal status defined by lack of menses for 2 years, oophorectomy, or medical ovarian suppression
Receiving first line endocrine-based therapy (tamoxifen, aromatase inhibitor, or fulvestrant; concurrent molecular therapy also allowed)
Sedentary (i.e., <60 minutes / week of exercise)
Age >18 years
BMI ≥ 18.5
Cleared for exercise participation as per screening clearance via PAR-Q+
Willingness to comply with all study-related procedures
Cleared for study participation as per screening consultation with an MSK Exercise Physiologist
Patients with "treated and stable" brain lesions of a duration of ≥ 2 months may be enrolled

Exclusion Criteria

Life expectancy <6 months
Enrollment onto any other therapeutic investigational study
Mental impairment leading to inability to cooperate
Concurrent participation in weight loss or other exercise programs
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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