Benefit of Placebo and Different Concentrations of Triamcinolone Acetonide in Nail Psoriasis

  • End date
    Dec 30, 2022
  • participants needed
  • sponsor
    Weill Medical College of Cornell University
Updated on 10 February 2022


This purpose of this study is to determine the lowest effective concentration of intralesional triamcinolone acetonide in the treatment of nail psoriasis.

Condition Nail Psoriasis, Nail Diseases
Treatment placebos, Triamcinolone Acetonide 2.5 mg/mL, Triamcinolone Acetonide 5.0 mg/mL, Triamcinolone Acetonide 7.5 mg/mL, Triamcinolone Acetonide 10 mg/mL
Clinical Study IdentifierNCT03991936
SponsorWeill Medical College of Cornell University
Last Modified on10 February 2022


Yes No Not Sure

Inclusion Criteria

At least 18 years of age
Diagnosed with nail psoriasis in at least 2 fingernails
Willing to give written informed consent and able to adhere to procedures and visit schedules
Must consent to having the fingernails photographed during the study period

Exclusion Criteria

Subject with any clinically significant condition or situation, other than the condition being studied that, in the opinion of the investigator, would interfere with study evaluations or optimal participation in the study. This is including, but not limited to: immunodeficiency, onychomycosis, any other nail condition other than psoriasis, allergy to triamcinolone acetonide, local anesthetic, normal saline, or any other material used for procedures
Subject who has received radiation therapy, chemotherapy, and/or immunosuppressive drugs within 6 months of study, and/or oral corticosteroids for >1 month within the 6 months of study (exception: inhaled steroids)
Subject known to have received treatment with investigational drugs or devices within 30 days prior to enrollment into this study
Subject who is unwilling to abstain from any cosmetic nail treatments outside those provided by the study clinic, beyond basic nail trimming (i.e. no spa nail treatments, no nail polish use, no other topical prescription nail medication)
Subject who is unwilling to abstain from any medical nail treatments on their nails other than the study intervention (i.e. topical steroids, anti-fungal creams) for the duration of the study intervention and for duration of the washout period (if applicable)
Subject who is part of the staff personnel directly involved with this study or a family member of the investigational study staff
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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