Substance Misuse To Psychosis for Stimulants

  • STATUS
    Recruiting
  • End date
    Mar 31, 2022
  • participants needed
    240
  • sponsor
    The University of Hong Kong
Updated on 25 January 2021
substance use disorders

Summary

In Hong Kong, less than 5% of stimulants abusers were reported to misuse these substances via injection. Also, it is well known that patients with co-morbid substance abuse/dependence and psychosis or schizophrenia-related disorders are prone to earlier treatment discontinuation and high oral medication non-adherence, resulting in poorer overall outcomes. With the recent availabilities of the 4-weekly long-acting injectable form of aripiprazole, and the 4-weekly and the 3-monthly long-acting injectable form of paliperidone palmitate, on the background of the surging phenomenon of stimulant misuses in Hong Kong, it is a timely opportunity to conduct an early pharmacotherapy intervention study to offer an evidence-based strategy aiming to stop individuals with substance use disorders with psychosis to develop into a more chronic disabling dependence or co-morbid state.

Details
Condition Chemotherapy, drug therapy, Schizophrenia and Related Disorders, Stimulant Abuse, Stimulant Dependence, Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis), Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis), Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis), Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis), pharmacological treatment, treatment with medication, medication therapy, drug therapies, pharmacotherapies, Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis)
Treatment Aripiprazole, Treatment As Usual, Paliperidone
Clinical Study IdentifierNCT03485417
SponsorThe University of Hong Kong
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 16 yrs and 50 yrs?
Gender: Male or Female
Do you have any of these conditions: Stimulant Dependence or Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis) or Stimulant Abuse or drug therapy or Schizophrenia and Re...?
Do you have any of these conditions: treatment with medication or Stimulant Abuse or Stimulant Dependence or Stimulant Use With Stimulant-Induced Psychotic Disorder (Diagnosis) or drug th...?
Stimulant use disorder with psychosis or positive stimulant urine test results
twice in a month with psychosis

Exclusion Criteria

Age <16 years old
Unable to read English or Chinese
Unable to give informed consent
Had been diagnosed to have Intellectual Disabilities (DSM-5) or Mental Retardation (ICD-10 F70-73)
Had been diagnosed to have Schizophrenia
Had been diagnosed to have other substance-induced psychotic or mood disorder, including alcohol
Had been diagnosed to have bipolar disorder viii. Had been diagnosed to have major depressive disorder with psychotic features
Had been taking any maintenance dose of oral antipsychotics continuously 12 weeks AND with psychotic symptoms in remission
Had been receiving any maintenance dose of long-acting injectable (LAI/depot) antipsychotics continuously 4 month AND with psychotic symptoms in remission
Had known hypersensitivity to risperidone (oral or LAI), paliperidone (oral or LAI), or aripiprazole (oral or LAI)
Had known history of tardive dyskinesia
Had known history of neuroleptic malignant syndrome
Pregnant
Mother currently breast-feeding
Had history of prolonged corrected QT interval (QTc) 500ms and/or known unstable or untreated cardiac disorder
Had mild to severe renal impairment with Glomerular Filtration Rate <80 mililitre /min
Clear my responses

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