Efficacy of Non-instrumental Pleural Chest Physiotherapy

  • STATUS
    Recruiting
  • End date
    Mar 6, 2021
  • participants needed
    82
  • sponsor
    Centre Hospitalier René Dubos
Updated on 26 October 2020
Investigator
Maryline DELATTRE
Primary Contact
H pital Dupuytren (1.2 mi away) Contact
+16 other location

Summary

The main purpose of this study is to assess efficacy of non instrumental pleural chest physiotherapy on the recovery of respiratory function, at hospital discharge or 15 days after beginning the pleural chest physiotherapy, compared to physiotherapy with standard mobilization, in patients with infectious pleural effusion, who have received usual medical treatment.

Description

Pleural effusions are defined by an abnormal amount of fluid in the pleural space. Those complicating a pneumonia are commonly encountered in pneumology departments, and their number are increasing. If not quickly treated, complications often occur: pleural adhesions, pleural thickening which can lead to a restrictive lung disease, or even to surgery. The average length of stay in hospital of this patients is 15 days. The management of infectious pleural effusion consists of removing the fluid from the pleural space (pleural puncturing or drainage), with or without fibrinolytics, antibiotics, and chest physiotherapy. Chest physiotherapy is often prescribed, but its benefits are largely based on empirical evidence. In the absence of recommendations, chest physiotherapy is done in heterogeneous ways, in France and abroad.

Pleural chest physiotherapy combines postural respiratory exercises, increased ventilation with dynamics expirations, and early inspiratory exercises, resulting in mobilization of pleura and pleural fluid. The hypothesis is that pleural chest physiotherapy thus makes it possible to fight against pleural effusion stagnation, to help resorption of pleural fluid, to limit formation of pleural adhesions and fixed restrictive lung disease. This should improve the recovery of respiratory function, and allow a shorter hospital stay, an improvement of the quality of life, earlier resumption of activities, and a reduction in the risk of complications.

Details
Treatment KRP-NI + KM, KM, KM
Clinical Study IdentifierNCT03861897
SponsorCentre Hospitalier René Dubos
Last Modified on26 October 2020

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Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Infectious Pleural Effusion?
eighteen years old
to be hospitalized for an infectious pleural outpouring
to have a liquid pleural outpouring diagnosed by echography or to scan thoracic
presence of a Exudate according to the criteria of Light, to have at least criteria
The ratio of pleural fluid protein to serum protein is greater than 0.5
The ratio of pleural fluid Lactate dehydrogenase (LDH) and serum LDH is greater than 0.6
The rate of pleural fluid LDH is > 2/3 upper limit of normal serum LDH of the laboratory concerned
presence of at least two of the following criteria
fever higher or equal 38C (100.4F)
thoracic pain
purulent sputum
purulent pleural effusion at the time of the exploring pleural puncture
hearth of crackling to the sounding
Inflammatory syndrome (CRP>15 mg/l and/or White blood cell >10 000 /mm3)
no known radiological hearth before
Having undergone an evacuation gesture going back to less forty-eight hours: evacuation pleural puncture or repeated pleural punctures or pleural drainage allowing the evacuation of at least 100cc of pleural fluid
Informed and having given its free, lit and express assent
Patients with affiliation to the social security system

Exclusion Criteria

Patient having undergone a thoracotomy or thoracoscopy in the six previous months
Patient having a pneumothorax
Patient reached of a tuberculosis
Patient unable to carry out a measurement of the vital capacity by portable spirometer at the inclusion
Pregnant woman or nursing
Patient having a life expectancy lower than three months
Proven or suspected pleural neoplasia disease
Patient hemodynamically unstable
Patient having a respiratory insufficiency requiring the introduction of an artificial ventilation
Patient carrying a chronic respiratory insufficiency under non-invasive ventilation with the long course
Patient unable to carry out the exercises of physiotherapy (problem of communication and/or comprehension and/or physical inaptitude)
Patient transplanted of a solid body, allograft or autograft of hematopoietic stem cells
Patient with a seropositivity for the known HIV and cluster of differentiation 4 (CD4) <250/mm3
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