Last updated on June 2019

Prospective Assessment of Premature Ventricular Contractions Suppression in Cardiomyopathy(PAPS)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Ventricular Premature Beats | Cardiomyopathy | or Systoles | Contractions
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • LV dysfunction (calculated LVEF < or equal to45% based on Echo) within 150 days of Enrollment (Day 0)
  • PVC burden > or equal to 10% by at least a 24-hr ambulatory Holter monitor (within 150 days of Enrollment (Day 0)

Exclusion Criteria:

  • Age < 18 years old
  • Current amiodarone use or within last 2 months
  • Current use of antiarrhythmic drugs class I or III
  • Contraindication to amiodarone use or any other class III antiarrhythmic
  • Severely symptomatic PVCs (unable to complete 3-month observation period)
  • Severe/significant CAD with planned revascularization in the near future
  • Complete AV block and pacemaker dependent
  • Pacemaker or ICD with >10% RV pacing
  • Severe valvular heart disease or planned valvular/cardiac surgery
  • Uncontrolled / untreated endocrinopathies
  • Uncontrolled HTN, (systolic BP >180mmHg or diastolic >110 mmHg)
  • Hypertrophic cardiomyopathy
  • Systemic infiltrative and immune disorders
  • Family history of dilated CM in a first degree relative
  • Alcohol abuse or illicit drug use
  • Contraindication to short-term acute anticoagulation (due to possible randomization to ablation)
  • Atrial fibrillation and flutter with rapid ventricular response with possible tachycardia-induced cardiomyopathy
  • Possible infectious etiology of cardiomyopathy
  • Pregnant or lactating women
  • Previous PVC ablation

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.